Clinical Impact of Baseline ctDNA RAS/BRAF Mutations on Conversion Surgery and Outcomes in First-Line Anti-EGFR Therapy for Advanced Colorectal Cancer
Epidermal growth factor receptor (EGFR) blockade combined with cytotoxic chemotherapy has substantially improved outcomes in unresectable metastatic colorectal cancer (mCRC), particularly in patients with left-sided RAS wild-type disease [...]
Authors
- Keiji Koda (ORCID: https://orcid.org/0000-0001-6073-9104)
- Hidekazu Kuramochi (ORCID: https://orcid.org/0000-0003-0875-7393)
- Takeshi Nagasaka (ORCID: https://orcid.org/0000-0002-4236-350X)
- Hajime Yokomizo
- Yuki Nakamura
- Keiji Hirata (ORCID: https://orcid.org/0000-0001-6461-5109)
- Hideyuki Ishida
- Yoshinori Kagawa
- Kozo Kataoka
- Kazuhiro Hiramatsu
- Nobuhisa Matsuhashi
- Takeshi Yamada (ORCID: https://orcid.org/0000-0002-1436-7482)
- Mitsukuni Suenaga (ORCID: https://orcid.org/0000-0002-6634-2893)
- Kiichi Sugimoto (ORCID: https://orcid.org/0000-0003-1210-2920)
- Hiroshi Yoshida
- Hiroshi Matsuoka (ORCID: https://orcid.org/0000-0002-7837-565X)
- Akihisa Matsuda (ORCID: https://orcid.org/0000-0002-6468-9375)
- Takao Takahashi
Institutions
- Mukogawa Women's University (JP)
- Tokyo Institute of Technology (JP)
- Hyogo Medical University (JP)
- University of Occupational and Environmental Health Japan (JP)
- Kawasaki Medical School (JP)
- Wakayama Medical University (JP)
- NTT Medical Center (JP)
- Juntendo University (JP)
- Gifu University of Medical Science (JP)
- Fujita Health University Hospital (JP)
- Tokyo Women's Medical University Adachi Medical Center (JP)
- Toyohashi Municipal Hospital (JP)
- Osaka International Cancer Institute (JP)
- Gifu University (JP)
- Nippon Medical School (JP)
- Hyogo University (JP)
- Saitama Medical University (JP)
- Teikyo University (JP)
Publication Details
- Journal
- Cancers
- Published
- 2026-05-22
- DOI
- https://doi.org/10.3390/cancers18111688
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00