Dyslipidemias associated with endocrine disorders: a position statement of the working group of the nutrition hormones and metabolism club of the italian society of endocrinology (SIE)
PURPOSE: Dyslipidemias are highly prevalent metabolic disturbances and represent a major driver of atherosclerotic cardiovascular disease. Beyond primary forms, numerous endocrine diseases induce secondary dyslipidemias that substantially modify lipid metabolism and contribute to cardiometabolic risk. This Position Statement of the Nutrition Hormones and Metabolism Club of the Italian Society of Endocrinology (SIE) aims to provide an updated, evidence-based synthesis of the pathophysiology, biochemical profile, and clinical impact of dyslipidemias associated with endocrine disorders. METHODS: A comprehensive review of current literature was performed, integrating epidemiological, mechanistic, and clinical data on lipid alterations across major endocrine diseases. Expert consensus was used to interpret evidence and formulate recommendations for clinical practice. RESULTS: Distinct and disease-specific dyslipidemic patterns were identified across conditions involving the hypothalamic-pituitary, thyroid, adrenal, gonadal, and GH/IGF-1 axes. Disorders such as acromegaly, growth hormone deficiency, hypothyroidism, hyperthyroidism, Cushing's syndrome, male and female hypogonadism, congenital adrenal hyperplasia, and polycystic ovary syndrome exhibit characteristic lipid abnormalities driven by hormonal dysregulation. These alterations contribute to increased cardiometabolic risk yet are frequently underrecognized and suboptimally managed. Early identification and tailored intervention may significantly improve outcomes. CONCLUSION: Endocrine-related dyslipidemias represent a clinically relevant but often overlooked contributor to cardiovascular risk. By summarizing current evidence and expert perspectives, this Position Statement aims to support clinicians in improving diagnosis, risk stratification, and management of lipid disorders associated with endocrine diseases, fostering a multidisciplinary approach to cardiometabolic prevention.
Authors
- Pasqualino Malandrino (ORCID: https://orcid.org/0000-0003-2474-0954)
- Ludovica Verde (ORCID: https://orcid.org/0000-0002-4583-8283)
- Gianluca Aimaretti (ORCID: https://orcid.org/0000-0002-6186-0106)
- Giuseppe Bellastella (ORCID: https://orcid.org/0000-0002-4748-321X)
- Gianluca Occhi (ORCID: https://orcid.org/0000-0003-4065-4677)
- Nunzia Prencipe (ORCID: https://orcid.org/0000-0002-9951-1796)
- Giorgio Arnaldi (ORCID: https://orcid.org/0000-0002-6204-3423)
- Valentina Gasco (ORCID: https://orcid.org/0000-0002-6491-5731)
- Massimiliano Caprio (ORCID: https://orcid.org/0000-0003-0722-7163)
- Marco Infante (ORCID: https://orcid.org/0000-0003-2032-8735)
- Manuela Albertelli (ORCID: https://orcid.org/0000-0002-5957-3247)
- Diego Ferone (ORCID: https://orcid.org/0000-0002-1410-6143)
- Annalisa Giandalia (ORCID: https://orcid.org/0000-0002-0778-4130)
- Alessandra Gambineri (ORCID: https://orcid.org/0000-0003-2242-6734)
- Luigi Barrea (ORCID: https://orcid.org/0000-0001-9054-456X)
- G Muscogiuri
- Francesco Frasca (ORCID: https://orcid.org/0000-0002-5556-3201)
- L Vignozzi
- Sebastio Perrini (ORCID: https://orcid.org/0000-0002-2728-7721)
- Federico Gatto (ORCID: https://orcid.org/0000-0002-5062-9208)
- SP Cannavò
- Marina Caputo
- Flavia Prodam
- Andrea Isidori
- Marco Bonomi
- Angelo Cignarelli
- Roberta Giordano
- Francesco Giorgino
- Ludovico Di Gioia
- Rosario Pivonello
- Chiara Simeoli
- Annamaria Colao
- Davide Ferrari
Institutions
- University of Messina (IT)
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- University of Arizona (US)
- University of Padua (IT)
- Vita-Salute San Raffaele University (IT)
- University of Milan (IT)
- San Raffaele University of Rome (IT)
- Azienda Ospedaliera Citta' della Salute e della Scienza di Torino (IT)
- Saint Camillus International University of Health and Medical Sciences (IT)
- Ospedale Garibaldi (IT)
- Istituto Nazionale di Fisica Nucleare, Sezione di Napoli (IT)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Federico II University Hospital (IT)
- Azienda USL di Bologna (IT)
- Pegaso University (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- Department of Medical Sciences (BY)
- IRCCS Ospedale San Raffaele (IT)
- IRCCS Istituto Auxologico Italiano (IT)
- LUM Jean Monnet University (IT)
- Surgical Specialties (United States) (US)
- Azienda Ospedaliera Universitaria Policlinico "G. Martino" (IT)
- Ospedale Generale Regionale Francesco Miulli (IT)
- Ospedale Policlinico San Martino (IT)
- University of Florence (IT)
- University of Turin (IT)
- University of Bari Aldo Moro (IT)
- University of Naples Federico II (IT)
- University of Genoa (IT)
- Sapienza University of Rome (IT)
- University of Palermo (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Journal of Endocrinological Investigation
- Published
- 2026-05-22
- DOI
- https://doi.org/10.1007/s40618-026-02862-y
- Primary Topic
- Pituitary Gland Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00