Artificial intelligence for detection and staging of Alzheimer’s disease using retinal images

OBJECTIVES: This is a protocol for a Cochrane Review (diagnostic). The objectives are as follows: To determine the diagnostic accuracy of AI algorithm-based retinal image reading for detecting referral-requiring Alzheimer's disease in adults who have behavioral symptoms or cognitive decline in the primary care setting. Secondary objectives Where data are available, we will investigate heterogeneity by incorporating covariates in a metaregression.