A rare case of inverted follicular keratosis on the knee

Inverted follicular keratosis (IFK) is a benign tumor of the follicular infundibulum, typically seen in elderly males on the face. Its occurrence in young patients or on extremities like the knee is extremely rare and often misdiagnosed as malignancy. Here, we present a case of an 18-year-old female with an asymptomatic plaque on the left knee, evolving from a papule to a hyperkeratotic plaque with erosions due to recurrent trauma. Histopathological examination revealed endophytic lobules of squamous epithelium with numerous squamous eddies and no atypia. IFK at atypical sites in young patients poses diagnostic challenges. This case emphasizes biopsy in chronic, non-responsive extremity lesions.

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Publication Details

Journal
Cosmoderma
Published
2026-05-21
DOI
https://doi.org/10.25259/csdm_25_2026
Primary Topic
Cancer and Skin Lesions
Type
article
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article

A rare case of inverted follicular keratosis on the knee

Fathimath Rubeena
Cosmoderma
Cancer and Skin Lesions
article

A rare case of inverted follicular keratosis on the knee

Fathimath Rubeena
article en

Abstract

Inverted follicular keratosis (IFK) is a benign tumor of the follicular infundibulum, typically seen in elderly males on the face. Its occurrence in young patients or on extremities like the knee is extremely rare and often misdiagnosed as malignancy. Here, we present a case of an 18-year-old female with an asymptomatic plaque on the left knee, evolving from a papule to a hyperkeratotic plaque with erosions due to recurrent trauma. Histopathological examination revealed endophytic lobules of squamous epithelium with numerous squamous eddies and no atypia. IFK at atypical sites in young patients poses diagnostic challenges. This case emphasizes biopsy in chronic, non-responsive extremity lesions.

CosmodermaVol. 6
Central University of Kerala (IN), Institute of Applied Dermatology (IN)
Good health and well-being
Openalex Percentile: Top 5%
Cancer and Skin Lesions
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