Development of AI based behavioral feature patterns on influencing asymptomatic cardiovascular disease attributes: a dataset standardization approach
Cardiovascular diseases (CVD) remain a major global health challenge, characterized by heterogeneous clinical attributes and multi-source data variability that limit reliable predictive modeling. Existing approaches primarily focus on independent feature analysis, often overlooking the interdependency between symptomatic and asymptomatic attributes. In this study, a transfer learning-based framework is proposed for cross-domain feature harmonization and interdependency-driven attribute modeling. Multi-source datasets, including MIMIC-III, Framingham Heart Study (FHS), and Cleveland Heart Disease (CHD), are integrated to construct a unified latent feature space. The proposed method systematically captures behavioral interdependencies between clinical attributes and introduces a confidence-calibrated influence scoring mechanism to enhance interpretability and reliability of predictions. Experimental results demonstrate improved performance, achieving a sensitivity of 92.37% and an F1-score of 0.8962. The findings highlight the effectiveness of interdependency-aware feature mapping in improving CVD risk characterization and provide a standardized framework for robust and explainable clinical decision support.
Authors
- Syed Muzamil Basha (ORCID: https://orcid.org/0000-0002-1169-3151)
- Syed Thouheed Ahmed (ORCID: https://orcid.org/0000-0002-2884-899X)
- Surbhi B. Khan
- Shakila Basheer
- Ali Algarni
- Mohammad Shabaz
- V. Sangeetha
Institutions
- Princess Nourah bint Abdulrahman University (SA)
- Marwadi University (IN)
- University of Salford (GB)
- Chitkara University (IN)
- King Khalid University (SA)
- REVA University (IN)
Publication Details
- Journal
- Scientific Reports
- Published
- 2026-05-21
- DOI
- https://doi.org/10.1038/s41598-026-52859-z
- Primary Topic
- Artificial Intelligence in Healthcare
- Type
- article
- Field-Weighted Citation Impact
- 0.00