Development of AI based behavioral feature patterns on influencing asymptomatic cardiovascular disease attributes: a dataset standardization approach

Cardiovascular diseases (CVD) remain a major global health challenge, characterized by heterogeneous clinical attributes and multi-source data variability that limit reliable predictive modeling. Existing approaches primarily focus on independent feature analysis, often overlooking the interdependency between symptomatic and asymptomatic attributes. In this study, a transfer learning-based framework is proposed for cross-domain feature harmonization and interdependency-driven attribute modeling. Multi-source datasets, including MIMIC-III, Framingham Heart Study (FHS), and Cleveland Heart Disease (CHD), are integrated to construct a unified latent feature space. The proposed method systematically captures behavioral interdependencies between clinical attributes and introduces a confidence-calibrated influence scoring mechanism to enhance interpretability and reliability of predictions. Experimental results demonstrate improved performance, achieving a sensitivity of 92.37% and an F1-score of 0.8962. The findings highlight the effectiveness of interdependency-aware feature mapping in improving CVD risk characterization and provide a standardized framework for robust and explainable clinical decision support.

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Publication Details

Journal
Scientific Reports
Published
2026-05-21
DOI
https://doi.org/10.1038/s41598-026-52859-z
Primary Topic
Artificial Intelligence in Healthcare
Type
article
Field-Weighted Citation Impact
0.00
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article

Development of AI based behavioral feature patterns on influencing asymptomatic cardiovascular disease attributes: a dataset standardization approach

Syed Muzamil Basha, Syed Thouheed Ahmed, Surbhi B. Khan, Shakila Basheer et al.
Scientific Reports
Artificial Intelligence in Healthcare
article

Development of AI based behavioral feature patterns on influencing asymptomatic cardiovascular disease attributes: a dataset standardization approach

Syed Muzamil Basha, Syed Thouheed Ahmed, Surbhi B. Khan, Shakila Basheer, Ali Algarni, Mohammad Shabaz, V. Sangeetha
article en

Abstract

Cardiovascular diseases (CVD) remain a major global health challenge, characterized by heterogeneous clinical attributes and multi-source data variability that limit reliable predictive modeling. Existing approaches primarily focus on independent feature analysis, often overlooking the interdependency between symptomatic and asymptomatic attributes. In this study, a transfer learning-based framework is proposed for cross-domain feature harmonization and interdependency-driven attribute modeling. Multi-source datasets, including MIMIC-III, Framingham Heart Study (FHS), and Cleveland Heart Disease (CHD), are integrated to construct a unified latent feature space. The proposed method systematically captures behavioral interdependencies between clinical attributes and introduces a confidence-calibrated influence scoring mechanism to enhance interpretability and reliability of predictions. Experimental results demonstrate improved performance, achieving a sensitivity of 92.37% and an F1-score of 0.8962. The findings highlight the effectiveness of interdependency-aware feature mapping in improving CVD risk characterization and provide a standardized framework for robust and explainable clinical decision support.

Scientific Reports
Princess Nourah bint Abdulrahman University (SA), Marwadi University (IN), University of Salford (GB), Chitkara University (IN), King Khalid University (SA), REVA University (IN)
Openalex Percentile: Top 3%
Artificial Intelligence in Healthcare
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Development of AI based behavioral feature patterns on influencing asymptomatic cardiovascular disease attributes: a dataset standardization approach — Syed Muzamil Basha, Syed Thouheed Ahmed, et al. · Scientific Reports (2026) | TGRS Research Map | TGRS