Protease Activity‐Independent, Th Cell‐Dependent Airway <scp>IL</scp> ‐33 Release Drives Eosinophilia in Mice Presensitized to Papain via <scp>SDS</scp> ‐Treated Skin

The data that support the findings of this study are available from the corresponding author upon reasonable request. Data S1. Supplementary methods. Figure S1. Airway inflammation induced by papain challenge is independent of the protease activity of papain used during the epicutaneous sensitization phase. Figure S2. Protease activity during the airway challenge phase contributes partially or not at all to airway inflammation in mice sensitized via SDS-treated skin. Figure S3. Supporting Information supporting the role of protease-independent, Th cell-dependent IL-33 release in airway eosinophilia. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

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Publication Details

Journal
Allergy
Published
2026-05-21
DOI
https://doi.org/10.1111/all.70375
Primary Topic
IL-33, ST2, and ILC Pathways
Type
article
Field-Weighted Citation Impact
0.00

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article

Protease Activity‐Independent, Th Cell‐Dependent Airway IL ‐33 Release Drives Eosinophilia in Mice Presensitized to Papain via SDS ‐Treated Skin

Kanako Kojima, Toru Kimitsu, Tomoko Yoshimura, Toshiro Takai et al.
Allergy
IL-33, ST2, and ILC Pathways
article

Protease Activity‐Independent, Th Cell‐Dependent Airway IL ‐33 Release Drives Eosinophilia in Mice Presensitized to Papain via SDS ‐Treated Skin

Kanako Kojima, Toru Kimitsu, Tomoko Yoshimura, Toshiro Takai, Kaito Muramatsu, Keiko Takada, Rei Watanabe, Seiji Kamijo, Saori Ichikawa, Saya Shimizu, Yurie Masutani, Zhaoyang Wang, K O Okumura, Nakae Susumu, Shuntaro Ishihara, Mengnan Chen, Hideoki Ogawa, Shigaku Ikeda, Sakiko Maruyama
article en

Abstract

The data that support the findings of this study are available from the corresponding author upon reasonable request. Data S1. Supplementary methods. Figure S1. Airway inflammation induced by papain challenge is independent of the protease activity of papain used during the epicutaneous sensitization phase. Figure S2. Protease activity during the airway challenge phase contributes partially or not at all to airway inflammation in mice sensitized via SDS-treated skin. Figure S3. Supporting Information supporting the role of protease-independent, Th cell-dependent IL-33 release in airway eosinophilia. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.

Allergy
Hiroshima University (JP), Japan Women's University (JP), Juntendo University (JP), Beijing Children’s Hospital (CN)
Japan Society for the Promotion of Science
Zero hunger
Openalex Percentile: Top 9%
IL-33, ST2, and ILC Pathways
DOISourceOpenAlex
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