Over four minutes of pyruvate T1 using chemically and physically induced deceleration of relaxation

Abstract [1- 13 C]pyruvate is the most widely used probe for hyperpolarized metabolic magnetic resonance imaging, with profound applications in tumor and inflammation diagnosis as well as treatment monitoring. The most fundamental hurdle to broader application, however, remains the rapid relaxation of polarization and the associated signal loss. Here, we report a method to address this challenge. Studying the nuclear spin relaxation dispersion of [1- 13 C]pyruvate across magnetic fields from 8 μT to 9.4 T, as a function of additives, solvents, and preparation methods, allows us to achieve T 1 relaxation times of up to four minutes. Such a long T 1 could enable reliable quality control and nearly polarization loss-free transport, further boosting the power of hyperpolarized metabolic MRI. The power of the optimized protocol for T 1 elongation in vitro is showcased by more than doubling the sensitivity in a metabolic experiment.

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Publication Details

Journal
Nature Communications
Published
2026-05-21
DOI
https://doi.org/10.1038/s41467-026-73214-w
Primary Topic
Advanced NMR Techniques and Applications
Type
article
Field-Weighted Citation Impact
0.00

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article

Over four minutes of pyruvate T1 using chemically and physically induced deceleration of relaxation

Andrey N. Pravdivtsev, Florin Teleanu, Jan‐Bernd Hövener, Huijing Zou et al.
Nature Communications
Advanced NMR Techniques and Applications
article

Over four minutes of pyruvate T1 using chemically and physically induced deceleration of relaxation

Andrey N. Pravdivtsev, Florin Teleanu, Jan‐Bernd Hövener, Huijing Zou, Alexej Jerschow, Ehtisham Rasool, Farhad Haj Mohamad, Josh P. Peters, Heiner Schäfer
article en

Abstract

Abstract [1- 13 C]pyruvate is the most widely used probe for hyperpolarized metabolic magnetic resonance imaging, with profound applications in tumor and inflammation diagnosis as well as treatment monitoring. The most fundamental hurdle to broader application, however, remains the rapid relaxation of polarization and the associated signal loss. Here, we report a method to address this challenge. Studying the nuclear spin relaxation dispersion of [1- 13 C]pyruvate across magnetic fields from 8 μT to 9.4 T, as a function of additives, solvents, and preparation methods, allows us to achieve T 1 relaxation times of up to four minutes. Such a long T 1 could enable reliable quality control and nearly polarization loss-free transport, further boosting the power of hyperpolarized metabolic MRI. The power of the optimized protocol for T 1 elongation in vitro is showcased by more than doubling the sensitivity in a metabolic experiment.

Nature CommunicationsVol. 17(1)
Horia Hulubei National Institute for R and D in Physics and Nuclear Engineering (RO), University Hospital Schleswig-Holstein (DE), Extreme Light Infrastructure - Nuclear Physics (RO), New York University (US), University of Lübeck (DE)
National Science Foundation, Deutsche Forschungsgemeinschaft, Bundesministerium für Bildung und Forschung, Studienstiftung des Deutschen Volkes
Openalex Percentile: Top 10%
Advanced NMR Techniques and Applications
DOIOpen Access PDFOpenAlex
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