Novel Compounds as TREM2 Modulators for Treating Alzheimer’s Disease, Parkinson’s Disease, Amyotrophic Lateral Sclerosis, Frontotemporal Dementia, and Nasu-Hakola Disease
Provided herein are novel compounds as TREM2 modulators, pharmaceutical compositions, use of such compounds in treating Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, and Nasu-Hakola disease, and processes for preparing such compounds.
Authors
- Anika R. Sabnis (ORCID: https://orcid.org/0009-0008-9940-6583)
- Ram W. Sabnis (ORCID: https://orcid.org/0000-0001-7289-0581)
Institutions
- Mayo Clinic (US)
Publication Details
- Journal
- ACS Medicinal Chemistry Letters
- Published
- 2026-05-21
- DOI
- https://doi.org/10.1021/acsmedchemlett.6c00249
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00