Current state of knowledge on the epidemiology, aetiology, diagnosis, and management of heart involvement in eosinophilia. A Clinical Consensus Statement of the ESC Working Group on Myocardial & Pericardial Diseases
Heart involvement in eosinophilia represents a rare entity with substantial cardiac morbidity and mortality. This disorder is often overlooked and diagnosed in its advanced stages. In a subgroup of patients with eosinophilic heart disease, peripheral blood eosinophilia may not be present, and the biopsy of the affected organ or tissue is essential to establish the correct diagnosis. In this clinical consensus statement, an expert consensus group reviews the epidemiology, aetiology, diagnosis, and management of eosinophilic heart disease. The aim of the document is to increase awareness about the cardiac involvement associated with eosinophilia in order to diagnose the disease in early phases and prevent deleterious heart damage and adverse outcomes of affected individuals. The spectrum of physiological and immunological derangements requires a multidisciplinary approach for optimal management of affected individuals.
Authors
- Angelos G. Rigopoulos (ORCID: https://orcid.org/0000-0003-0735-2319)
- M Merlo
- J Kuusisto
- Mary N. Sheppard (ORCID: https://orcid.org/0000-0003-2724-3881)
- Silvia Castelleti
- M Imazio
- František Sedlák (ORCID: https://orcid.org/0000-0002-5565-8462)
- Marc R. Dweck (ORCID: https://orcid.org/0000-0001-9847-5917)
- Andrea Frustaci (ORCID: https://orcid.org/0000-0002-5748-0725)
- Steffen Erhard Petersen (ORCID: https://orcid.org/0000-0003-4622-5160)
- G Lazaros
- Antonio Brucato
- Antonis Pantazis
- Matteo Cameli (ORCID: https://orcid.org/0000-0003-3872-8964)
- Petr Kuchynka
- Carsten Tschöpe (ORCID: https://orcid.org/0000-0001-5243-8985)
- Bettina Heidecker
- Arsen D Ristić
- Karin Klingel (ORCID: https://orcid.org/0000-0003-0203-2498)
- Leslie T Cooper
Institutions
- University of Siena (IT)
- University of Udine (IT)
- St Bartholomew's Hospital (GB)
- St George's Hospital (GB)
- University of Trieste (IT)
- University of Eastern Finland (FI)
- University of Milan (IT)
- Charles University (CZ)
- Royal Brompton & Harefield NHS Foundation Trust (GB)
- Jacksonville College (US)
- University of Belgrade (RS)
- Ospedale Santa Maria della Misericordia di Udine (IT)
- Berlin-Brandenburger Centrum für Regenerative Therapien (DE)
- German Centre for Cardiovascular Research (DE)
- Mitera Hospital (GR)
- IRCCS Istituto Auxologico Italiano (IT)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- ERN GUARD-Heart (NL)
- Deutsches Herzzentrum München (DE)
- William Harvey Research Institute (GB)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- General University Hospital in Prague (CZ)
- Azienda Sanitaria Universitaria Integrata di Trieste (IT)
- Hippocration General Hospital (GR)
- Misericordia University (US)
- Charité - Universitätsmedizin Berlin (DE)
- University of Edinburgh (GB)
Publication Details
- Journal
- European Journal of Heart Failure
- Published
- 2026-05-21
- DOI
- https://doi.org/10.1093/ejhf/xuag043
- Primary Topic
- Eosinophilic Disorders and Syndromes
- Type
- article
- Field-Weighted Citation Impact
- 0.00