Cardiac Radiation Dose and Subclinical Coronary Artery Disease Progression after Breast Cancer Radiotherapy: 2-year Cardiac CT Results from the EARLY-HEART Study
Two years after breast cancer radiotherapy, cardiac CT demonstrated dose-associated progression of coronary artery calcification, particularly in the presence of preexisting calcification, while coronary stenosis progression was unrelated to radiation dose.
Authors
- Johannes A. Langendijk (ORCID: https://orcid.org/0000-0003-1083-372X)
- Daan Spoor (ORCID: https://orcid.org/0000-0001-6246-8387)
- Arantxa Eraso (ORCID: https://orcid.org/0000-0002-5378-7834)
- Médéa Locquet (ORCID: https://orcid.org/0000-0002-9961-5931)
- Sophie Jacob (ORCID: https://orcid.org/0000-0003-1729-305X)
- Anne P.G. Crijns (ORCID: https://orcid.org/0000-0002-3157-0626)
- Montse Ventura (ORCID: https://orcid.org/0000-0002-3366-8360)
- R Vliegenthart
- Manuela Fiuza
- Damian Craiem
- E Mousseaux
- Susana Constantino Rosa Santos (ORCID: https://orcid.org/0000-0002-5711-1292)
- Stephanie E. Combs
- Susana Constantino
- for the MEDIRAD EARLY-HEART investigators
- Kai Borm (ORCID: https://orcid.org/0009-0005-8580-890X)
Institutions
- Institut de Radioprotection et de Sûreté Nucléaire (FR)
- University Medical Center Groningen (NL)
- University of Lisbon (PT)
- Inserm (FR)
- University of Groningen (NL)
- Favaloro University (AR)
- Université Paris Cité (FR)
- Helmholtz Zentrum München (DE)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Institut Català d'Oncologia (ES)
- Hôpital Européen (FR)
- German Marine Research Consortium (DE)
- Paris Cardiovascular Research Center (FR)
- Technical University of Munich (DE)
Publication Details
- Journal
- Radiology Cardiothoracic Imaging
- Published
- 2026-05-21
- DOI
- https://doi.org/10.1148/ryct.250342
- Primary Topic
- Cardiac Imaging and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Euratom Research and Training Programme
- Horizon 2020