Dysmetabolic nephropathies in persons with bone and joint pathology

Objective: Dysmetabolic nephropathies are characterized by disturbances in oxalate, urate and phosphate metabolism and have beensuggested as triggering factors for bone and joint pathology. The aim of this study was determine the frequency of dysmetabolicnephropathies in patients with bone and joint pathology and to compare the laboratory parameters between patients with dysmetabolicnephropathy and controls.Patients and Methods: Patients with bone and joint pathology (coxarthrosis, gonarthrosis, ligamentum ruptures, and bone fractures)were enrolled in the study. Dysmetabolic nephropathy (characterized by hyperoxaluria, uraturia or phosphaturia) was revealed in9% of patients with bone and joint pathology. Sixty-one patients without dysmetabolic nephropathy served as a control group. Thepatients underwent general clinical and biochemical examinations.Results: The persons with bone and joint pathology and the presence of dysmetabolic nephropathy demonstrated a prevalence ofhyperoxaluria (59%) with less frequency of uraturia (25.7%) and phosphaturia (15.1%). Hyperoxaluria was associated with a highincidence of ligamentum ruptures and bone fractures (21.6%). The persons with hyperoxaluria demonstrated higher levels ofeosinophils, platelets, white blood cells (WBCs), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), thymol probe, andserum alkaline phosphatase. The persons with dysmetabolic nephropathy showed higher levels of WBCs, ESR, alkaline phosphatase,creatinine, thymol probe, and CRP (P