D-ribose-L-cysteine protects against rotenone-induced neurotoxicity in <i>Drosophila</i> via redox, neurotransmitter, and DDC gene regulation
through antioxidant, anti-inflammatory, and anti-apoptotic mechanisms, possibly via enhanced GSH synthesis and dopamine regulation. Although we cannot fully rule out the possibility that DRLC affected rotenone ingestion or feeding behavior, the fact that ROT-dependent phenotypes persisted in the absence of DRLC and were only selectively reversed by DRLC suggests a neuroprotective effect.
Authors
- Olumayowa Kolawole Idowu (ORCID: https://orcid.org/0000-0002-6605-3266)
- A. Sogbesan
- Tope Gafar Atere (ORCID: https://orcid.org/0000-0001-9349-0990)
- Olufunke Olubusola Dosumu
- Adewale Emmanuel Ajibade
- Omosola Fisayo Anifowose
- Oluwatomisin Olalekan Faniyan
Institutions
- Università di Camerino (IT)
- Ekiti State University (NG)
- University of Lagos (NG)
- Adeleke University (NG)
- Osun State University (NG)
Publication Details
- Journal
- Journal of Neurogenetics
- Published
- 2026-05-21
- DOI
- https://doi.org/10.1080/01677063.2026.2658577
- Primary Topic
- Sulfur Compounds in Biology
- Type
- article
- Field-Weighted Citation Impact
- 0.00