Double agent: a congenital mole changing its identity

A 10-year-old boy presented with a congenital melanocytic naevus over the right face and neck showing gradual central lightening and surrounding depigmentation over one year. Examination revealed a 7 × 5 cm 2 hyperpigmented plaque with peripheral flat depigmenting areas, grey hair and perifollicular pigmentation. Dermoscopy demonstrated heterogeneous pigment with white structureless areas, while ultraviolet fluorescent dermoscopy highlighted sharp lesion margins. Findings suggested spontaneous regression of CMN with vitiligo-like depigmentation, likely due to immune-mediated melanocyte destruction. Recognition of this benign process is important to distinguish it from melanoma-associated regression and avoid unnecessary interventions, while ensuring appropriate clinical monitoring for atypical changes.

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Publication Details

Journal
Pigment International
Published
2026-05-21
DOI
https://doi.org/10.4103/pigmentinternational_2_26
Primary Topic
Cutaneous Melanoma Detection and Management
Type
article
Field-Weighted Citation Impact
0.00
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article

Double agent: a congenital mole changing its identity

Manju Daroach, Payal Chauhan, A G Bhagwat
Pigment International
Cutaneous Melanoma Detection and Management
article

Double agent: a congenital mole changing its identity

Manju Daroach, Payal Chauhan, A G Bhagwat
article en

Abstract

A 10-year-old boy presented with a congenital melanocytic naevus over the right face and neck showing gradual central lightening and surrounding depigmentation over one year. Examination revealed a 7 × 5 cm 2 hyperpigmented plaque with peripheral flat depigmenting areas, grey hair and perifollicular pigmentation. Dermoscopy demonstrated heterogeneous pigment with white structureless areas, while ultraviolet fluorescent dermoscopy highlighted sharp lesion margins. Findings suggested spontaneous regression of CMN with vitiligo-like depigmentation, likely due to immune-mediated melanocyte destruction. Recognition of this benign process is important to distinguish it from melanoma-associated regression and avoid unnecessary interventions, while ensuring appropriate clinical monitoring for atypical changes.

Pigment International
All India Institute of Medical Sciences (IN)
Openalex Percentile: Top 8%
Cutaneous Melanoma Detection and Management
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