The CRT-Estimands Framework for Cluster Randomized Trials
This Viewpoint discusses some specific challenges in defining estimands for cluster randomized trials and illustrates how the CRT-Estimands Framework can be applied to improve the interpretation of trial results.
Authors
- Brennan C Kahan (ORCID: https://orcid.org/0000-0001-9957-0844)
- F Li
- Frank Bretz
- Gary S. Collins
Institutions
- Novartis (Switzerland) (CH)
- Birmingham City University (GB)
- University College Birmingham (GB)
- Yale University (US)
- MRC Clinical Trials Unit at UCL (GB)
- University College London (GB)
- Medical University of Vienna (AT)
- University of Birmingham (GB)
Publication Details
- Journal
- JAMA
- Published
- 2026-05-21
- DOI
- https://doi.org/10.1001/jama.2026.8368
- Primary Topic
- Meta-analysis and systematic reviews
- Type
- article
- Field-Weighted Citation Impact
- 0.00