Coil‑Tag conjugation: a next gen site‑specific ADC fabrication technology

“Coil‑Tag bioconjugation represents a powerful shift toward modular, programmable, and supramolecular construction of ADCs with site‑specificity and defined DARs.”As the ADC field matures and demand for greater homogeneity and site-specificity intensifies, new bioconjugation platforms are emerging to address the limitations of classical cysteine-maleimide and lysine-amide chemistries. Grace Yang, Alina Ringaci, and Mark W Grinstaff provide insights into the Coil-Tag platform, a modular, supramolecular conjugation strategy based on the self-assembly of engineered α-helical coiled-coil peptides. They highlight its design principles, its advantages over existing site-specific methods, and its expanding utility across ADC fabrication, CAR-T cell engineering, diagnostics, and biomaterials.