Copper-Catalyzed Remote Asymmetric Three-Component Sulfonylation Using SO <sub>2</sub> as the Sulfur Source to Access Chiral Allylic Sulfones
A copper-catalyzed enantioselective sulfonylation of yne-allylic esters with sulfur dioxide and cyclopropan-1-ols is reported. This three-component reaction proceeds via selective ε-addition of γ-keto sulfinate to copper-allenylidene intermediates, enabling efficient synthesis of chiral allylic sulfones under mild conditions. The protocol features high enantioselectivity (up to 96% ee), broad functional group compatibility, and good yields.
Authors
- Xiang Ma (ORCID: https://orcid.org/0000-0002-8679-4491)
- Huijing Xiang (ORCID: https://orcid.org/0000-0002-7465-3392)
- Xingguang Li (ORCID: https://orcid.org/0000-0002-3617-1827)
- Jiaxing Guo
- Jiale Li
- Shuning Liu
- Wenli Yan
Institutions
- Shanghai University (CN)
- East China University of Science and Technology (CN)
- Institute of Molecular Functional Materials (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-05-19
- DOI
- https://doi.org/10.1021/acs.orglett.6c01600
- Primary Topic
- Sulfur-Based Synthesis Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00