Darzens Reaction of 2,2,2‐Trifluoroacetophenones With α‐Fluoroindanones
Darzens condensations of 2,2,2‐trifluoroacetophenones with α‐fluoroindanones were developed. A variety of tetrasubstituted α,β‐epoxyketones were constructed using this protocol in moderate to good yields (up to 76%), with moderate to excellent diastereoselectivities (up to 94:6 dr).
Authors
- Yingjie Lin (ORCID: https://orcid.org/0000-0001-8492-6609)
- Dapeng Liang (ORCID: https://orcid.org/0000-0002-2342-6683)
- Shangzhi Wang
- Jungang Cao (ORCID: https://orcid.org/0000-0002-5113-3239)
- Meiyan Zhao
- Zhonglin Wei
- Haifeng Duan (ORCID: https://orcid.org/0009-0000-3078-131X)
Institutions
- Jilin University (CN)
- Changchun University (CN)
Publication Details
- Journal
- European Journal of Organic Chemistry
- Published
- 2026-05-19
- DOI
- https://doi.org/10.1002/ejoc.70551
- Primary Topic
- Fluorine in Organic Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.00