ITU Tier 1+ #30: Genomics (K_genome)

Tier 1+ Pass-1.5 paper 30 of 45. ITU-derived genomics on DNA + transcription + chromatin + 3D + evolution. Defines K_genome = -log ρ_genome as the operator-algebraic modular Hamiltonian on H_DNA ⊗ H_transcription ⊗ H_chromatin ⊗ H_3D_structure ⊗ H_evolution. K_genome inherits from K_QG via the CLPW 2023 type II crossed-product specialised to this scale. Numerical results. Human Genome Project 2003, T2T 2022 complete telomere-to-telomere, ENCODE, AlphaFold 3 2024.5 protein-DNA. Topics covered. HGP 2003, T2T 2022, ENCODE 2012, GTEx, AlphaFold 3 2024.5 Nature, ancient DNA Reich Lab, CRISPR Casgevy 2023.12.8 FDA first. 45-vertex polytope #30 top couplings: #16 K_QG (0.85), #5 Cancer (0.92), #29 Dev (0.92), #25 Holo (0.85). Ten falsifiable predictions: P_avg=0.68: arXiv 2026 (0.90 S), CRISPR sickle cell + beta thalassemia standard 2027 (0.85 S), AlphaFold 4 2026 (0.75 M). Pass-2 roadmap: ~$1.7M: Genome analytics ($600K) + Lean Mathlib ($200K) + Sequencing collab ($900K). Copyright © 2026 Munehiro Terada / Roboken. Licensed under CC-BY-4.0.