mechanical stress-mediated ferritinophagy aggravates cartilage endplate degeneration via Piezo1-NCOA4-ZBP1 axis
silencing attenuates Z-mtDNA-ZBP1-NFKB axis-driven IVDD. Collectively, our findings suggest that mechanical overload induces ferritinophagy-dependent CEP degeneration via PIEZO1 activation and subsequent upregulation of the Z-mtDNA-ZBP1-NFKB axis, which might furnish a therapeutic target for IVDD.
Institutions
- Beijing Institute of Technology (CN)
- Shandong University (CN)
- Nankai University (CN)
- Chinese PLA General Hospital (CN)
- Fourth People’s Hospital of Jinan (CN)
- Beijing Radiation Center (CN)
- Seventh People's Hospital of Shanghai (CN)
Publication Details
- Journal
- Autophagy
- Published
- 2026-05-19
- DOI
- https://doi.org/10.1080/15548627.2026.2677183
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Beijing Municipality