CT of Soft Tissue Infections: Current and Future Perspectives from Diagnosis to Treatment

Background/Objectives: Skin and soft-tissue infections represent a critical diagnostic challenge in the emergency department, requiring rapid differentiation between superficial processes and life-threatening necrotizing conditions. Methods: This clinical update analyzes the central role of CT in the assessment of these pathologies, proposing a management-oriented algorithm to support risk stratification and therapeutic planning. Results: By reviewing the fundamental semiological features of contrast-enhanced CT, this work highlights how the identification of critical markers directly guides the choice between medical management and urgent surgical intervention. In addition to consolidating protocols based on conventional CT, the article examines current perspectives and clinical limitations of emerging technologies, including Spectral CT (DECT and PCD-CT) and artificial intelligence, evaluating their potential to improve image quality and tissue characterization. Conclusions: In conclusion, while technological evolution offers new diagnostic frontiers, a rigorous and systematic interpretation of CT findings remains the fundamental pillar for optimizing patient outcomes and reducing unnecessary interventions.