Ginger supplementation in children with oligoarticular juvenile idiopathic arthritis: A triple-blind randomized clinical trial.

Objective: This study aimed to investigate the effect of ginger supplementation on treatment responses in children with oligoarticular juvenile idiopathic arthritis (oligo-JIA). Materials and Methods: rhizomes) or a placebo twice daily for three months, along with standard treatment. The response to therapy was measured using the American College of Rheumatology Pediatric 30, 50, 70, and 90 response criteria (ACR-Pedi 30, 50, 70, and 90) after three months of supplementation. Results: ACR-Pedi 30, 50, 70, and 90 responses were significantly higher among those receiving ginger supplement (p<0.001, p<0.001, p<0.001, and p=0.001, respectively). Conclusion: In this study, ginger supplementation improved ACR-Pedi 30, 50, 70 and 90 responses in pediatric patients with oligo-JIA. Given its safety profile and anti-inflammatory and immunomodulatory properties, ginger supplementation may enhance therapeutic responses in this clinical setting. However, due to certain limitations within our study, further research is essential to confirm these promising findings.