Urolithin A safeguards against diabetes-induced pathospermia and embryotoxicity in rats.

Objective: Diabetes mellitus (DM) as a chronic disease can negatively affect male fertility due to endocrine and metabolic pathways disruption. This study was implemented to appraise the possible beneficial effects of urolithin A (UA), a natural polyphenol produced by the gut microbiota, against DM adverse effects on epididymal sperms and pre-implantation embryo development in mature rats. Materials and Methods: fertilization (IVF) success rate were rigorously assessed. Results: fertility, and embryological (IVF, and two-cell embryos, morulae, and blastocysts formation rates) parameters. Conclusion: This study's outcomes spotlighted the promising protective functions of UA in DM-associated male reproductive disorders in rats, owing its weighty anti-oxidative properties.