Cancer During Pregnancy: Navigating Clinical and Research Challenges

The incidence of cancer during pregnancy is rising, yet scientific understanding and clinical management remain underdeveloped. Delayed diagnoses, limited therapeutic options, and lack of safety data exacerbate the clinical challenges of treating cancer during pregnancy. Further, the biology of gestational cancers is poorly understood due to the scarcity of model systems and mechanistic studies. This manuscript presents a multidisciplinary perspective from a group of researchers and clinicians to evaluate the current state of pregnancy-associated cancers, identify unmet clinical and biological questions, and propose strategies to improve diagnosis, treatment, and maternal–fetal outcomes.

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Publication Details

Journal
Current Oncology
Published
2026-05-19
DOI
https://doi.org/10.3390/curroncol33050296
Primary Topic
Cancer Risks and Factors
Type
article
Field-Weighted Citation Impact
0.00

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article

Cancer During Pregnancy: Navigating Clinical and Research Challenges

Current Oncology
Cancer Risks and Factors
article

Cancer During Pregnancy: Navigating Clinical and Research Challenges

article en

Abstract

The incidence of cancer during pregnancy is rising, yet scientific understanding and clinical management remain underdeveloped. Delayed diagnoses, limited therapeutic options, and lack of safety data exacerbate the clinical challenges of treating cancer during pregnancy. Further, the biology of gestational cancers is poorly understood due to the scarcity of model systems and mechanistic studies. This manuscript presents a multidisciplinary perspective from a group of researchers and clinicians to evaluate the current state of pregnancy-associated cancers, identify unmet clinical and biological questions, and propose strategies to improve diagnosis, treatment, and maternal–fetal outcomes.

Current OncologyVol. 33(5)
Northwell Health (US), Memorial Sloan Kettering Cancer Center (US), Harvard University (US), Hofstra University (US), Cold Spring Harbor Laboratory (US), University of Michigan (US), Universitair Ziekenhuis Leuven (BE), Yale University (US), Stony Brook School (US), National Human Genome Research Institute (US), New Hope Fertility Center (US), Donald & Barbara Zucker School of Medicine at Hofstra/Northwell (US), Parker Institute for Cancer Immunotherapy (US), Babylon Breast Cancer Coalition (US), Dana-Farber Cancer Institute (US), Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital (NL), Tisch Hospital (US), University of Colorado Cancer Center (US), University of Pennsylvania Health System (US), Eunice Kennedy Shriver National Institute of Child Health and Human Development (US), Cooper University Health Care (US), University of Colorado Anschutz Medical Campus (US), Stony Brook University (US), University of Colorado Denver (US), Icahn School of Medicine at Mount Sinai (US), KU Leuven (BE)
Breast Cancer Research Foundation
Good health and well-being
Openalex Percentile: Top 6%
Cancer Risks and Factors
DOIOpen Access PDFOpenAlex
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