Practical Lithium–Sulfur Batteries: An Integrated Design Roadmap from High‐Loading Cathodes to High‐Energy Pouch Cells

The transition to a sustainable energy future requires electrochemical storage systems that surpass conventional lithium-ion batteries. The lithium-sulfur (Li-S) battery, with its high theoretical energy density and use of abundant sulfur, is a paramount contender for next-generation applications. However, its commercialization is hindered by intrinsic challenges: the insulating nature of sulfur, the deleterious polysulfide shuttle effect, and severe volumetric expansion. For over a decade, research has focused on nanomaterial engineering under idealized laboratory conditions, yielding metrics often divorced from practical reality. This review argues that overcoming these barriers necessitates a decisive paradigm shift from isolated material breakthroughs to the synergistic integration of three interdependent frontiers. First, the scale-up imperative, translating nanoscale innovations into manufacturable, high-loading electrodes validated in lean-electrolyte pouch cells (where the electrolyte-to-sulfur ratio, E/S is minimized). Second, electrolyte-cathode synergy, co-engineering an integrated system where components are mutually reinforcing. Third, systematic, data-driven optimization using advanced operando characterization, multi-physics modeling, and artificial intelligence (AI) to navigate the complex parameter space. By deconstructing these gaps, we synthesize a pragmatic roadmap emphasizing integration and practical validation. We posit that only through coordinated advances across these interconnected domains can the transformative potential of high-energy-density lithium-sulfur batteries be fully realized for applications like electric aviation and grid storage.