PTK2/FAK inhibition triggers TMED9-mediated protective autophagy in pancreatic cancer cell via enhancing ERGIC-ERES contact
. Collectively, our work unveils a previously unrecognized mechanism of FAKi-mediated autophagy induction and provides new insights for developing targeted therapies against PDAC.
Authors
- M Zhang
- Xiaowen Zhang (ORCID: https://orcid.org/0000-0002-0072-2439)
- Yue Cheng (ORCID: https://orcid.org/0009-0007-7036-2129)
- Yuehua Chen (ORCID: https://orcid.org/0009-0006-1343-7449)
- Li Li (ORCID: https://orcid.org/0009-0003-4636-9487)
- Wan Tang (ORCID: https://orcid.org/0000-0001-5693-3342)
- Q Pan
- J Chai
- He-Dan Xu
- Si-Rui Yu
- Jia-Hong Lu
- Sen Liang
- Ming-Yue Wu (ORCID: https://orcid.org/0009-0009-1285-2378)
Institutions
- Army Medical University (CN)
- University of Macau (MO)
- Southwest Hospital (CN)
Publication Details
- Journal
- Autophagy
- Published
- 2026-05-17
- DOI
- https://doi.org/10.1080/15548627.2026.2676079
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China