Severe Pneumocystis jirovecii Pneumonia as the Sentinel Presentation of BENTA Disease: Case Report of a 3-month-old Infant
Pneumocystis jirovecii can cause severe pneumonia in HIV-negative infants with underlying immunodeficiency. We report an infant with prior acute respiratory distress syndrome and recurrent infections unresponsive to antibiotics. Persistent interstitial opacities led to immunologic testing, revealing T-cell lymphopenia and a CARD11 mutation. Respiratory polymerase chain reaction confirmed P. jirovecii . Treatment with trimethoprim–sulfamethoxazole and intravenous immunoglobulin led to recovery.
Authors
- Mario Javier Forero-Manzano
- José Antonio Vargas-Soler
- Andrés Felipe Rubio-Duarte (ORCID: https://orcid.org/0000-0001-9091-5367)
- Alexandra Hurtado-Ortiz
- María Paula Garcés-Rodríguez (ORCID: https://orcid.org/0009-0006-5683-804X)
- Keyla Meneses-Silvera (ORCID: https://orcid.org/0000-0002-5612-7014)
Institutions
- Fundación Cardiovascular de Colombia (CO)
- Laboratoire de Biologie Structurale de la Cellule (FR)
- Adult Congenital Heart Association (US)
- Universidad De Santander (CO)
Publication Details
- Journal
- The Pediatric Infectious Disease Journal
- Published
- 2026-05-18
- DOI
- https://doi.org/10.1097/inf.0000000000005288
- Primary Topic
- Pneumocystis jirovecii pneumonia detection and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00