The Hippo Pathway in Intestinal Regeneration, Fetal Reprogramming, and Tumorigenesis
) intestinal stem cells and epithelial integrity. Cross talk between Hippo, Wingless-related integration site (WNT), transforming growth factor β (TGF-β), and p53 signaling orchestrates this dynamic repair process, with precise temporal control of YAP essential for successful regeneration. Dysregulation of these interactions contributes to colorectal cancer tumorigenesis, highlighting the Hippo pathway as a central hub linking intestinal homeostasis, regeneration, and cancer.
Authors
- Jeffrey L. Wrana (ORCID: https://orcid.org/0000-0003-0932-0644)
- Vanessa Man
Institutions
- University of Toronto (CA)
- Lunenfeld-Tanenbaum Research Institute (CA)
Publication Details
- Journal
- Cold Spring Harbor Perspectives in Biology
- Published
- 2026-05-18
- DOI
- https://doi.org/10.1101/cshperspect.a041915
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- preprint