Safety analysis and parameters of cardiopulmonary exercise test in patients with ventricular aneurysm after myocardial infarction

Assessing ventricular aneurysm (VA) after myocardial infarction (MI) with Cardiopulmonary Exercise Testing (CPET) are lack of evidence. This study aimed to evaluate the safety and characteristics of CPET in patients with post-MI VA. A total of 803 CPET were completed. The patients were divided into VA and non-VA groups according to echocardiography results (60 vs 743). The primary endpoint events about safety were set as blood pressure (BP) drops, exercise-related myocardial ischemia, and severe arrhythmias, while secondary endpoint events were set as abnormal BP response and frequent ventricular premature beats. The differences about CPET parameters were compared by propensity score matching analysis. No fatal adverse events were observed during or within 2 h post-CPET, while endpoint adverse events were observed in 15 cases (1.87%) which all occurred in the non-VA group. The maximum voluntary ventilation and left ventricular ejection fraction were statistically lower in the VA group, while left ventricular end-diastolic diameter was larger. A logistic regression analysis suggested that development of VA or not was not the risk factor for the occurrence of the primary endpoint events during CPET. No increase in the incidence of adverse events during CPET was observed in the VA versus non-VA group.