Cyanoacrylamide derivatives as a novel amoebicidal agents against Acanthamoeba spp.
values against both the trophozoite and cyst stages compared to the other derivatives. Furthermore, these compounds demonstrated low cytotoxicity against the murine macrophage cell line J774A.1. Analysis of the mode of action evidenced that both cyanoacrylamides triggered programmed cell death (PCD) and autophagy in A. griffini trophozoites. Additionally, these compounds induced severe cytoskeletal alterations, specifically characterised by the disorganisation and disruption of the actin and tubulin networks.
Authors
- María Reyes-Batllé (ORCID: https://orcid.org/0000-0002-2290-5746)
- José Enrique Piñero (ORCID: https://orcid.org/0000-0001-6233-8224)
- Inés Sifaoui (ORCID: https://orcid.org/0000-0002-5649-8333)
- Samuel Delgado‐Hernández (ORCID: https://orcid.org/0000-0001-9952-6480)
- David Tejedor (ORCID: https://orcid.org/0000-0003-3262-0776)
- Rubén L. Rodríguez-Expósito
- Jacob Lorenzo-Morales
Institutions
- Consejo Superior de Investigaciones Científicas (ES)
- Universidad de La Laguna (ES)
- Hospital Universitario de Canarias (ES)
- Instituto de Productos Naturales y Agrobiología (ES)
Publication Details
- Journal
- Biomedicine & Pharmacotherapy
- Published
- 2026-05-18
- DOI
- https://doi.org/10.1016/j.biopha.2026.119388
- Primary Topic
- Antimicrobial agents and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Centro de Investigación Biotecnológica en Red de Enfermedades Infecciosas
- Cabildo de Tenerife