Sublingual Lipoma: A Case Report and Review of the Literature

Sublingual lipoma is an exceptionally rare benign lesion of the floor of the mouth and a potential diagnostic challenge because its clinical and radiologic features can overlap with those of other benign lesions. We report the case of a 37-year-old woman who presented with a painless mass in the left floor of the mouth. Magnetic resonance imaging suggested an epidermoid cyst, whereas surgical excision and histopathological examination confirmed a lipoma involving the sublingual gland region. The postoperative course was uneventful. This case highlights that sublingual lipoma should be considered in the differential diagnosis of benign-appearing floor-of-mouth masses, as preoperative imaging may be misleading.

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Publication Details

Journal
Journal of Craniofacial Surgery
Published
2026-05-18
DOI
https://doi.org/10.1097/scs.0000000000012907
Primary Topic
Teratomas and Epidermoid Cysts
Type
article
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Sublingual Lipoma: A Case Report and Review of the Literature

Xinwei Zuo, Hongjin Chen, Li Z, Liufang Qian et al.
Journal of Craniofacial Surgery
Teratomas and Epidermoid Cysts
article

Sublingual Lipoma: A Case Report and Review of the Literature

Xinwei Zuo, Hongjin Chen, Li Z, Liufang Qian, Shuguang Liu, Jingpeng Liu
article en

Abstract

Sublingual lipoma is an exceptionally rare benign lesion of the floor of the mouth and a potential diagnostic challenge because its clinical and radiologic features can overlap with those of other benign lesions. We report the case of a 37-year-old woman who presented with a painless mass in the left floor of the mouth. Magnetic resonance imaging suggested an epidermoid cyst, whereas surgical excision and histopathological examination confirmed a lipoma involving the sublingual gland region. The postoperative course was uneventful. This case highlights that sublingual lipoma should be considered in the differential diagnosis of benign-appearing floor-of-mouth masses, as preoperative imaging may be misleading.

Journal of Craniofacial Surgery
CITIC Group (China) (CN), Annual Reviews (US), Southern Medical University (CN)
Gender equality
Openalex Percentile: Top 5%
Teratomas and Epidermoid Cysts
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