KIBRA impairs DNA damage repair and suppresses osteosarcoma progression by inhibiting the Wnt/β-catenin signaling activity

, KIBRA overexpression inhibited tumor growth and impaired DNA damage repair, as evidenced by increased γH2AX foci and decreased RAD51 expression. Mechanistically, KIBRA inhibited the Wnt/β-catenin signaling activity, and activating this pathway by SKL2001 reversed the inhibitory effects of KIBRA on osteosarcoma progression and DNA damage repair. Therefore, KIBRA acts as a tumor suppressor in osteosarcoma by inhibiting the Wnt/β-catenin signaling activity, thereby impairing DNA damage repair and suppressing malignant progression.