Noninvasive Diagnosis of Parkinson’s Disease via High-Coverage Exhaled Metabolomics: A Proof-of-Concept Study
= 0.049), reflecting the burden of neurodegeneration. Our findings demonstrate that breath metabolomics represents a noninvasive, rapid, and scalable approach with substantial clinical potential for PD screening and disease monitoring. The eMS system provides a promising strategy to support early PD diagnosis and dynamic monitoring of disease progression.
Authors
- Zhifeng Tang (ORCID: https://orcid.org/0000-0001-5591-8175)
- X.C. Li (ORCID: https://orcid.org/0000-0002-5981-2762)
- Keda Zhang (ORCID: https://orcid.org/0000-0001-7512-3281)
- Xiaolong Chen (ORCID: https://orcid.org/0000-0003-1566-6975)
- Le Chen (ORCID: https://orcid.org/0000-0002-0382-5863)
- Wenbiao Xian
- Chen Li
- Wenxin Huang
- Xin Luo
- Wen He
- Shixian Hu
Institutions
- National Sun Yat-sen University (TW)
- Sun Yat-sen University (CN)
- Bürgerhospital Frankfurt am Main (DE)
- Sun Yat-sen Memorial Hospital (CN)
- Zhongshan Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- First Affiliated Hospital of Chinese PLA General Hospital (CN)
- Shenzhen Technology University (CN)
- Institute of Atmospheric Physics (CN)
- Sciencetech (Canada) (CA)
Publication Details
- Journal
- Analytical Chemistry
- Published
- 2026-05-17
- DOI
- https://doi.org/10.1021/acs.analchem.6c00422
- Primary Topic
- Advanced Chemical Sensor Technologies
- Type
- article
- Field-Weighted Citation Impact
- 0.00