Peptide-mediated inhibition of aberrant chaperone-mediated autophagy in pericytes prevents glioblastoma progression through MAPT/tau secretion
PC: GB-conditioned pericyte; GSCs: glioblastoma stem cells; HSPA8/HSC70: heat shock protein family A (Hsp70) member 8; LAMP2A: lysosome associated membrane protein 2A; LI: lysosomal inhibitors; MAPT/tau: microtubule associated protein tau; NAc: N-acetylcysteine; PC: pericyte; PCGB: pericyte-glioblastoma coculture; PDGFRB: platelet derived growth factor receptor beta; ROS: Reactive oxygen species; SPARC: secreted protein acidic and cysteine rich; TME: tumor microenvironment; TNT: tunneling nanotubes.
Authors
- M. Salinas (ORCID: https://orcid.org/0000-0002-5859-0969)
- M. Molina (ORCID: https://orcid.org/0000-0001-9190-6948)
- Rut Valdor (ORCID: https://orcid.org/0000-0002-2681-0779)
- Ana María Cuervo (ORCID: https://orcid.org/0000-0002-0771-700X)
- Isabel María Martínez
- Sylviane Muller
- Elena Naranjo
Institutions
- Albert Einstein College of Medicine (US)
- School of Advanced Study (GB)
- Institut de Science et d'Ingénierie Supramoléculaires (FR)
- Instituto Murciano de Investigación Biosanitaria (ES)
- Université de Strasbourg (FR)
- Universidad de Murcia (ES)
Publication Details
- Journal
- Autophagy
- Published
- 2026-05-18
- DOI
- https://doi.org/10.1080/15548627.2026.2672700
- Primary Topic
- Heat shock proteins research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hevolution Foundation
- “la Caixa” Foundation
- European Regional Development Fund
- Agencia Estatal de Investigación
- European Social Fund