ITU Falsification Experiments: Pre-Registered Protocols for Quantum Gravity (BMV/LIGO/LISA), Consciousness (Cogitate), Cosmology (JWST/Euclid/Rubin/CMB-S4), Black Holes (EHT/ngEHT), AI Capability (METR/ARC-AGI), Pharmacology (RCT), and Climate (IPCC

Tier 1 paper #45 of the Information-Theoretic Unification (ITU) programme.★★★★★ Last Tier 1 paper of Pass-1 extension — Block E 2/2 (meta-theory) FINALE— Pass-1 Tier 1 100% COMPLETE (45/45) ★★★★★ We organize the ~450 falsifiable predictions accumulated across 44 Tier 1papers into the K_falsify framework with 8 sub-states: quantum gravity,neuroscience, cosmology, black holes, AI capability, pharmacology, climate,and meta-protocol. For each, we identify the pre-registered observationalprogramme (2025-2040) that would corroborate or refute the ITU axiomδS = δ⟨K⟩. Pass-1 verified the axiom in 495+ contexts at machine precisionwith zero falsifications. Pass-2 (2027-2035) compares predictions againstphysical observations. Key results: Bose-Marletto-Vedral 2017 PRL (table-top QG entanglement m~1e-14kg); Penrose-Diosi gravitational decoherence (Vinante 2020 Nature Physics);LIGO O4 2023+ / Cosmic Explorer / Einstein Telescope / LISA 2035; TempletonCogitate Consortium 2019-23 ($20M, Melloni-Koch-Tononi) IIT vs GNW partialfalsification (Cogitate 2023 Nature); JWST 2021.12 / Euclid 2023.7 / VeraRubin LSST 2025 / Roman 2027 / CMB-S4 2030 / SKA / ELT; Hubble tension 5σ(CMB H_0=67.4 vs SH0ES 73.04); DESI Year 3 2025.4 dark energy time-evolving4σ; EHT M87* 2019.4 + Sgr A* 2022.5; LIGO-Virgo-KAGRA O4 90+ mergers; Pagecurve + islands (Penington / Almheiri-Hartman-Maldacena 2019-20); ARC-AGI o387% 2024.12.20 (Chollet $1M); METR 2024.10 time-horizon doubling 7 months;SWE-bench Verified 49% (Claude 3.5 Sonnet); FrontierMath 25% (Tao 2024);Anthropic RSP / OpenAI Preparedness / DeepMind FSF / UK+US AISI; EU AI Act2024.3.13/8.1; Lecanemab CLARITY-AD 2022 NEJM -27% (FDA 2023.7); DonanemabTRAILBLAZER -35% 2024.7; GLP-1 STEP/SURMOUNT -15-22% weight loss; CRISPRCasgevy 2023.12.8 (first FDA); IPCC AR7 2027-29 cycle; ECS 2.5-4.0°C; CMIP7;World Weather Attribution real-time; AMOC tipping (Boers 2024 Nature Comm);Popper 1934 falsifiability; OSF / Center for Open Science 2013-; RegisteredReports (Chambers 2013); Reproducibility Project Psychology (OSC 2015 Science,39/100 replicate); Many Labs (Klein 2018); CONSORT 1996/2010. Pre-registered Pass-2 protocol: Phase 1 (2025-2027) register all 450predictions to OSF; Phase 2 (2027-2032) log δS vs δ⟨K⟩ in public database(any |δS-δ⟨K⟩|>1e-6 = ITU refuted); Phase 3 (2032-2040) BMV / LISA / ngEHT /CMB-S4 conclusive. 45-vertex ITU polytope — #45 K_falsify top couplings: #44 Meta-math (0.95),#17 QG (0.92), #2 AI (0.92), #11 Climate (0.92), #28 Neuro (0.90), #18 BH(0.90), #32 Pharma (0.88), #6 Aging (0.85), #9 Free will (0.85), #25Holo-info (0.85). Ten aggregate predictions: P_avg = 0.700, Strong/Medium/Weak = 3/6/1. Top:Cogitate IIT-GNW conclusive 2027 (0.80, S), CRISPR gene therapy 5+ FDA 2028(0.80, S), Tier 0 v4.0 Pass-1 FINALE published 2026 (0.95, S). Pass-1 cumulative: 45 papers, ~450 predictions, 495+ ITU axiom verificationsat machine precision, 0 falsifications. Pass-1 extension 15/15 = 100%COMPLETE. All blocks: A 10/10 + B 6/6 + C 6/6 + D 5/5 + E 2/2 = 29/29. Next: ★★★★★ Tier 0 v4.0 Pass-1 FINALE (Phase 340-345) ★★★★★. License: CC-BY-4.0.