Organization Quanta and the Unity of Physics and Physiology. From Gradient Indeterminacy to Multilevel Coherence

Physics and physiology appear to inhabit separate worlds, connected only through a long chain of intermediate disciplines: chemistry, biochemistry, cell biology, systems biology. Yet a growing body of evidence---from quantum biology to ubiquitous scaling constants---suggests that physical principles operate directly in biological systems, without requiring translation through intermediate levels. This paper proposes that the Gradient Indeterminacy (I-G) framework and the Multilevel Recursive Coherence (MRC) framework are not merely compatible: they are expressions of the same underlying principle at different scales. We introduce organization quanta---level-specific minimal units of coherence---and coupling factors that modulate constraints according to network topology. The result is a unified framework where health is distance from saturation of fundamental constraints, healing is reconstruction of coupling, and the boundary between physics and physiology dissolves. We anchor our proposal in observed phenomena (quantum biology, scaling constants, coherence-health correlations) before developing the formal framework, and conclude with falsifiable predictions and open research directions.This paper focuses on the physics-biology interface; a companion paper develops the full hierarchy of organization quanta including psychological and sociological levels.