Epidemiological, Clinical and Allergic Profile of Patients With Dyshidrotic Eczema (Acute and Recurrent Vesicular Dermatitis): Evaluation of the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy ( <scp>REIDAC</scp> )

ABSTRACT Background Dyshidrotic eczema (DE), also termed acute and recurrent vesicular dermatitis, is a vesicular clinical pattern of hand eczema (HE) with heterogeneous aetiologies. Objectives To characterise the clinical‐allergological profile of patients with DE and to compare it with non‐DE HE subtypes. Methods A multicentre, retrospective, observational study was conducted using data from the Spanish Contact Dermatitis Registry (2019–2024). Results Of 4378 patients with HE, 559 were diagnosed with DE. A longer median disease duration (24 vs. 14 months) and more frequent palmoplantar involvement (16% vs. 7%) were observed in DE compared with non‐DE HE. At least one positive patch test was identified in 43% of DE versus 52% in non‐DE HE. Although overall sensitisation patterns were largely comparable, DE showed lower sensitisation rates to 2‐HEMA, carba mix and thiuram mix. Occupational factors were less frequently implicated in DE (9% vs. 29%) compared with non‐DE HE. Conclusions Despite a high overall frequency of contact allergen sensitisation, the pattern of findings suggests that the dyshidrotic phenotype may follow a clinical course less dependent on external or occupational triggers, pointing towards a relatively greater contribution of endogenous factors compared with other HE subtypes.

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Publication Details

Journal
Contact Dermatitis
Published
2026-05-17
DOI
https://doi.org/10.1111/cod.70184
Primary Topic
Contact Dermatitis and Allergies
Type
article
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article

Epidemiological, Clinical and Allergic Profile of Patients With Dyshidrotic Eczema (Acute and Recurrent Vesicular Dermatitis): Evaluation of the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy ( REIDAC )

Paloma Sánchez‐Pedreño Guillén, Marta Andreu Barasoain, E Serra-Baldrich, Carmen Paredes‐Suárez et al.
Contact Dermatitis
Contact Dermatitis and Allergies
article

Epidemiological, Clinical and Allergic Profile of Patients With Dyshidrotic Eczema (Acute and Recurrent Vesicular Dermatitis): Evaluation of the Spanish Registry of Research in Contact Dermatitis and Cutaneous Allergy ( REIDAC )

Paloma Sánchez‐Pedreño Guillén, Marta Andreu Barasoain, E Serra-Baldrich, Carmen Paredes‐Suárez, Javier Miquel‐Miquel, Violeta Zaragoza‐Ninet, Tatiana Sanz‐Sánchez, Marta Elosua‐González, Leopoldo Borrego, Raquel Barba-Martín, Ricardo González‐Pérez, Susana Córdoba‐Guijarro, Inmaculada Ruiz‐González, María Elena Gatica‐Ortega, José-Juan Pereyra-Rodríguez, Mercedes Rodríguez-Serna, Juan Francisco Silvestre-Salvador, Gemma Melé‐Ninot, Francisco J. Navarro‐Triviño, Pablo Chicharro, Ana M. Giménez‐Arnau, José Manuel Carrascosa‐Carrillo, Araceli Sánchez‐Gilo, Francisco Javier Ortiz de Frutos, Enrique Gómez de la Fuente, Miguel Ángel Descalzo, María Antonia Pastor‐Nieto, Pedro Mercader‐García, Ignacio García‐Doval
article en

Abstract

ABSTRACT Background Dyshidrotic eczema (DE), also termed acute and recurrent vesicular dermatitis, is a vesicular clinical pattern of hand eczema (HE) with heterogeneous aetiologies. Objectives To characterise the clinical‐allergological profile of patients with DE and to compare it with non‐DE HE subtypes. Methods A multicentre, retrospective, observational study was conducted using data from the Spanish Contact Dermatitis Registry (2019–2024). Results Of 4378 patients with HE, 559 were diagnosed with DE. A longer median disease duration (24 vs. 14 months) and more frequent palmoplantar involvement (16% vs. 7%) were observed in DE compared with non‐DE HE. At least one positive patch test was identified in 43% of DE versus 52% in non‐DE HE. Although overall sensitisation patterns were largely comparable, DE showed lower sensitisation rates to 2‐HEMA, carba mix and thiuram mix. Occupational factors were less frequently implicated in DE (9% vs. 29%) compared with non‐DE HE. Conclusions Despite a high overall frequency of contact allergen sensitisation, the pattern of findings suggests that the dyshidrotic phenotype may follow a clinical course less dependent on external or occupational triggers, pointing towards a relatively greater contribution of endogenous factors compared with other HE subtypes.

Contact Dermatitis
Universidad de Las Palmas de Gran Canaria (ES), University of the Basque Country (ES), Universitat Pompeu Fabra (ES), Universidad Rey Juan Carlos (ES), Hospital Universitario Insular de Gran Canaria (ES), Hospital de Sant Pau (ES), University Hospital Complex Of Vigo (ES), Hospital Universitari i Politècnic La Fe (ES), Research Institute Hospital 12 de Octubre (ES), Hospital General Universitario Morales Meseguer (ES), Hospital Universitario de Guadalajara (ES), Complejo Hospitalario Universitario de Santiago (ES), Hospital Universitario Fundación Alcorcón (ES), Hospital Universitario Rey Juan Carlos (ES), Universidad Europea (MX), Spanish Academy of Dermatology and Venereology (ES), Hospital Universitario Puerta de Hierro Majadahonda (ES), Hospital Universitario Araba (ES), Instituto de Investigación Biosanitaria de Granada (ES), Hospital Arnau de Vilanova (ES), Leitat Technological Center (ES), Hospital General Universitario De Valencia (ES), Hospital Universitario Fundación Jiménez Díaz (ES), Hospital Universitario de La Princesa (ES), Hospital Del Mar (ES), Hospital Universitari Sagrat Cor (ES), Hospital General Universitario de Alicante Doctor Balmis (ES), Complexo Hospitalario Universitario A Coruña (ES), Hospital Universitario de Fuenlabrada (ES), Hospital Universitario Virgen de la Arrixaca (ES), Hospital Universitario Virgen del Rocío (ES), Hospital Universitari Germans Trias i Pujol (ES), Hospital Universitario Infanta Sofía (ES), Hospital Universitario Ramón y Cajal (ES), Complejo Hospitalario Universitario de Toledo (ES), Complejo Asistencial Universitario de Palencia (ES), Universidad de Sevilla (ES), Universidad Europea de Madrid (ES)
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Contact Dermatitis and Allergies
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