Inorganic nitrogen metabolic reprogramming of the gut microbiome drives fecal microbiota transplantation in ulcerative colitis
supplementation during FMT significantly improves microbial engraftment fidelity, which is correlated with increased anti-inflammatory responses and attenuated colonic pathology. Network meta-analysis of multiple clinical datasets further substantiates the prognostic value of donor gut microbial IN-uc in UC remission. Our findings establish the gut microbial IN-uc as an ecological driver of microbiota engraftment and present a rationally designed microbial therapy that optimizes FMT efficacy through targeted metabolic reprogramming.
Authors
- Yinlong Wang
- Qihang Hou (ORCID: https://orcid.org/0000-0002-0037-0402)
- Jiongyan Liu
- Xinying Lv
- Haonan Tong
- Huimei Wang
- Xin Yang (ORCID: https://orcid.org/0000-0002-0811-6599)
- Yan Zhao
- Xiaojun Yang
- Shuixiang He (ORCID: https://orcid.org/0000-0002-4832-1896)
- Yanli Liu (ORCID: https://orcid.org/0000-0002-8966-5011)
- Shengru Wu (ORCID: https://orcid.org/0000-0002-1046-3477)
- Juan Du (ORCID: https://orcid.org/0000-0001-7649-9571)
Institutions
- Karolinska Institutet (SE)
- North West Agriculture and Forestry University (CN)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Northwest A&F University (CN)
Publication Details
- Journal
- Nature Communications
- Published
- 2026-05-18
- DOI
- https://doi.org/10.1038/s41467-026-73290-y
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00