<scp>IFI16</scp> /204 Promotes Dendritic Cell Activation and Anti‐Hepatocellular Carcinoma Efficacy via the <scp>STING</scp> – <scp>TBK1</scp> – <scp>IRF3</scp> Signalling Pathway
IFI16 (the murine homologue is IFI204) is an intracellular double-stranded DNA (dsDNA) pattern recognition receptor (PRR) that plays a crucial role in bridging innate and adaptive immunity. However, its function in dendritic cell (DC) activation and anti-hepatocellular carcinoma (HCC) efficacy remains poorly characterised. This study demonstrates that IFI16 promotes DC maturation, functional activation and antitumor immunity. This effect occurs through activation of the STING-TBK1-IRF3 signalling pathway. Our findings establish IFI16 as a key molecule enabling DCs to sense dsDNA and initiate antitumor responses. Consequently, targeting IFI16 and its downstream STING-TBK1-IRF3 signalling pathway represents a potential therapeutic strategy for hepatocellular carcinoma.
Authors
- H J Wang
- X.C. Li (ORCID: https://orcid.org/0000-0002-5981-2762)
- Xi Zhang (ORCID: https://orcid.org/0000-0002-4638-3997)
- Haitao Zhang (ORCID: https://orcid.org/0000-0002-1639-4089)
- He Wenjing
- Ma Yx
- Gao Y (ORCID: https://orcid.org/0000-0001-6502-9910)
- Wang Shuai
- Zhang Long
Institutions
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Immunology
- Published
- 2026-05-17
- DOI
- https://doi.org/10.1111/imm.70152
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- Guangzhou Municipal Science and Technology Project
- Science and Technology Planning Project of Guangdong Province