MEF2A nuclear translocation mediated by ROCK phosphorylation promotes EZH2 expression and peritoneal fibrosis
, MEF2A knockdown alleviated PF in rats undergoing to long-term PD. Consistently, oral fasudil treatment inhibited the dialysis-induced upregulation of MEF2A and EMT markers. These results reveal a novel ROCK/MEF2A/EZH2 axis in PF pathogenesis, highlighting MEF2A as a potential therapeutic target.
Authors
- Q-X Wang
- Zhikang Sun
- Dandan Chen
- Ying Xu
Institutions
- Central South University (CN)
- Shandong Provincial Hospital (CN)
- Xiangya Hospital Central South University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Renal Failure
- Published
- 2026-05-17
- DOI
- https://doi.org/10.1080/0886022x.2026.2664318
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China