Developmental and dynamic systems: insights for sex/gender research

Recent work incorporating gender into sex differences research has complicated the interpretation of both physiological and behavioral differences between women and men, which are traditionally interpreted as driven by "biological" sex-related variables. Alternative conceptualizations have been proposed to capture the complex relationship between sex and gender, such as sex/gender entanglement. Blurring the boundaries between gender and sex, the organism and its environments, this perspective has created a need for theoretical and methodological approaches that can be used to investigate the emergence of structures and behaviors in complex systems. Here, we review the foundational concepts of developmental and dynamic systems theories, which can serve as frameworks within which to investigate the emergence of complex phenomena. We then provide examples of empirical research programs that demonstrate the benefit of these frameworks in the context of sex/gender research.

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Publication Details

Journal
Biology of Sex Differences
Published
2026-05-16
DOI
https://doi.org/10.1186/s13293-026-00920-x
Primary Topic
Sex and Gender in Healthcare
Type
article
Field-Weighted Citation Impact
0.00

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article

Developmental and dynamic systems: insights for sex/gender research

Donna L. Maney, Giordana Grossi, Annie Duchesne
Biology of Sex Differences
Sex and Gender in Healthcare
article

Developmental and dynamic systems: insights for sex/gender research

Donna L. Maney, Giordana Grossi, Annie Duchesne
article en

Abstract

Recent work incorporating gender into sex differences research has complicated the interpretation of both physiological and behavioral differences between women and men, which are traditionally interpreted as driven by "biological" sex-related variables. Alternative conceptualizations have been proposed to capture the complex relationship between sex and gender, such as sex/gender entanglement. Blurring the boundaries between gender and sex, the organism and its environments, this perspective has created a need for theoretical and methodological approaches that can be used to investigate the emergence of structures and behaviors in complex systems. Here, we review the foundational concepts of developmental and dynamic systems theories, which can serve as frameworks within which to investigate the emergence of complex phenomena. We then provide examples of empirical research programs that demonstrate the benefit of these frameworks in the context of sex/gender research.

Biology of Sex Differences
Emory University (US), University of Northern British Columbia (CA), SUNY New Paltz (US), Innovation and Economic Development Trois Rivières (CA), Université du Québec à Trois-Rivières (CA)
National Institutes of Health
Gender equality
Openalex Percentile: Top 4%
Sex and Gender in Healthcare
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Developmental and dynamic systems: insights for sex/gender research — Donna L. Maney, Giordana Grossi, et al. · Biology of Sex Differences (2026) | TGRS Research Map | TGRS