Capryol-Ethyl oleate self-microemulsifying system for improved intestinal absorption and hypoglycemic activity of empagliflozin
studies demonstrated significant augmentation in oral hypoglycemic activity of EMPA, revealed as 1.45-fold elevation in area under blood glucose reduction curve after administration of SMEDDS compared to EMPA aqueous dispersion. SMEDDS formulation successfully improved intestinal absorption, hypoglycemic efficacy and hence oral bioavailability of EMPA.
Authors
- Dalia H. Abdelkader (ORCID: https://orcid.org/0000-0002-6277-3565)
- Gamal M. El Maghraby (ORCID: https://orcid.org/0000-0001-5531-710X)
- Eglal M. Hathout (ORCID: https://orcid.org/0009-0007-4075-7138)
- Suleiman S. Eltokhy (ORCID: https://orcid.org/0000-0002-5121-6771)
Institutions
- Tanta University (EG)
Publication Details
- Journal
- Pharmaceutical Development and Technology
- Published
- 2026-05-16
- DOI
- https://doi.org/10.1080/10837450.2026.2674731
- Primary Topic
- Advanced Drug Delivery Systems
- Type
- article
- Field-Weighted Citation Impact
- 0.00