Kan-Li Geometry as a Cross-Scale Consciousness Metric: A Unified Framework from Allosteric Proteins to Whole-Brain Functional Integration

We propose Kan-Li co-activation as a scale-invariant geometric signature of integrative capacity, with three converging lines of evidence: (1) Molecular — ZT_potential ranks #1 in RF importance for allosteric classification (AUC 0.913, d=-0.894, p<0.001, n=569). (2) EEG — HT-alphaSI discriminates meditation vs. focus with d=1.51, p=3e-14 (n=50). (3) Connectome — HCP 400-ROI Limbic-DMN co-activation hierarchy: meditation > wakefulness > propofol anesthesia. The Zhongtian operator (E_ZT=40) serves as the harmonic bridge across all scales. Cross-scale neuroreceptor ZT_potential (8 PDB structures) confirms functional flexibility hierarchy. Framework complements IIT (Tononi 2004) and GWT (Baars 1988).