Kan-Li Geometry as a Cross-Scale Consciousness Metric: A Unified Framework from Allosteric Proteins to Whole-Brain Functional Integration (Version 2 — Corrected)
Version 2 corrects three methodological issues from v1 (DOI: 10.5281/zenodo.20228701): (1) Table 3 consciousness-state CI values are now explicitly labeled as in silico simulations (literature-guided FC perturbation of HCP wakefulness connectome), not direct measurements. (2) Table 4 neuroreceptor ZT_potential values are computed via an approximate Ramachandran-projection pipeline, not directly comparable to AlloBench Laplacian-projection values. (3) The claim 'largest EEG consciousness effect size' is removed; replaced with 'unusually large (d=1.51; cf. Casali et al. 2013 d~1.0-1.3)'. Empirical evidence retained: (a) AlloBench n=569: ZT_potential RF rank #1 (0.120), AUC 0.913, Kan-Li d=-0.894, p<0.001. (b) EEG n=50: HT-alphaSI d=1.51, p=3e-14. (c) HCP wakefulness n=33: SC/FC Kan-Li tension 0.044/0.060 (empirical). In silico predictions (Table 3 rows 2-4) and approximate neuroreceptor rankings (Table 4) are clearly labeled as model outputs requiring experimental validation.
Authors
- Yao-Kai Kao
Institutions
- Allen Institute for Brain Science (US)
- Taipei Institute of Pathology (TW)
Publication Details
- Journal
- Zenodo (CERN European Organization for Nuclear Research)
- Published
- 2026-05-16
- DOI
- https://doi.org/10.5281/zenodo.20228791
- Primary Topic
- Functional Brain Connectivity Studies
- Type
- preprint