The Mathematics of Neurological Failure: Predicting Disease Onset through a Simulation of Delay-Induced Fragility

Current neurological diagnostic frameworks rely on probabilistic biomarkers that provide a static "snapshot" of pathology but lack the temporal resolution required to predict clinical onset. This research presents a deterministic approach to neuro-prognostics by modeling neurodegeneration as a systemic collapse governed by the laws of delay-induced fragility. By introducing the Srivastava Constant (v_s) and utilizing a high-dimensional digital twin framework, we simulate the kinetic decay of neuronal stability. Our findings indicate that neurological failure is a predictable phase transition that occurs when signal delays exceed a critical biological threshold. This model provides a robust mathematical foundation for forecasting the 15-year prophylactic window, shifting the clinical paradigm from reactive diagnosis to deterministic prevention.

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Publication Details

Journal
Zenodo (CERN European Organization for Nuclear Research)
Published
2026-05-16
DOI
https://doi.org/10.5281/zenodo.20242013
Primary Topic
Functional Brain Connectivity Studies
Type
preprint
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preprint

The Mathematics of Neurological Failure: Predicting Disease Onset through a Simulation of Delay-Induced Fragility

Tanmay Srivastava
Zenodo (CERN European Organization for Nuclear Research)
Functional Brain Connectivity Studies
preprint

The Mathematics of Neurological Failure: Predicting Disease Onset through a Simulation of Delay-Induced Fragility

Tanmay Srivastava
preprint en

Abstract

Current neurological diagnostic frameworks rely on probabilistic biomarkers that provide a static "snapshot" of pathology but lack the temporal resolution required to predict clinical onset. This research presents a deterministic approach to neuro-prognostics by modeling neurodegeneration as a systemic collapse governed by the laws of delay-induced fragility. By introducing the Srivastava Constant (v_s) and utilizing a high-dimensional digital twin framework, we simulate the kinetic decay of neuronal stability. Our findings indicate that neurological failure is a predictable phase transition that occurs when signal delays exceed a critical biological threshold. This model provides a robust mathematical foundation for forecasting the 15-year prophylactic window, shifting the clinical paradigm from reactive diagnosis to deterministic prevention.

Zenodo (CERN European Organization for Nuclear Research)
Aljazeera University (SY)
Good health and well-being
Functional Brain Connectivity Studies
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The Mathematics of Neurological Failure: Predicting Disease Onset through a Simulation of Delay-Induced Fragility — Tanmay Srivastava · Zenodo (CERN European Organization for Nuclear Research) (2026) | TGRS Research Map | TGRS