A REVIEW ON ANALYTICAL METHODS FOR INDIVIDUAL AND SIMULTANEOUS ANALYSIS OF LISINOPRIL AND HYDROCHLOROTHIAZIDE(HCTZ)

Lisinopril is an (ACE) angiotensin-converting enzyme inhibitor and is used in the treatment of high blood pressure, heart failure, and heart attacks. It works by blocking the production of a potent blood vessel constrictor (angiotensin II), leading to relaxed blood vessels, reduced fluid volume, and lower blood pressure. Hydrochlorothiazide is a diuretic drug used for treatment of high blood pressure(hypertension) and accumulation of fluid (edema). It works by blocking salt and fluid reabsorption from the urine in the kidneys, causing increased urine output (dieresis). The combination of lisinopril and hydrochlorothiazide provides a synergistic approach to managing Hypertension. This combination is effective, well-tolerated, and convenient. Numerous analytical methods have been developed for the determination of lisinopril and hydrochlorothiazide. These methods include a reverse phase chromatography method with UV detection (HPLC-UV), A high performance thin layer chromatography (HPTLC), UV Spectrophotometric, A reverse phase high performance liquid chromatography (RP-HPLC), A liquid chromatography-tandem mass spectrometry (LC-MS/MS).