Biodegradable polymer-based nanoparticles for gene delivery – potentials and limitations

The biomedical sciences have witnessed recently an accelerated development, the thing that positively affected disease therapy approaches, especially at the molecular and genetic level; however, these newly emerging strategies need an appropriate delivery vectors and biodegradable polymeric micro/nanoparticles (as a non-viral vectors) represent an invaluable tool for this purpose owing to its variable chemical structure, nature, biocompatibility, and bio-degradability. The aim of this review is to shed the light on the feasibility of biodegradable polymeric micro/nanoparticles as a gene delivery, taking into account also the potential limitations.