A REVIEW ON: PHARMACOLOGICAL EVALUATION OF CYPERUS ROTUNDUS_ON DOXORUBICIN-INDUCED CARDIOTOXICITY IN EXPERIMENTAL RATS

Doxorubicin is commonly used against solid and haematological malignancies but causes cardio toxicity marked by elevated cardiac biomarkers, oxidative stress, structural heart tissue damage, and eventual heart failure. Key mechanisms include reactive oxygen species (ROS) generation, lipid peroxidation, inflammatory cytokine upregulation, and apoptotic signaling in cardiomyocytes. Enhancing antioxidant and anti-inflammatory defenses remains a promising approach to mitigate these effects. Cyperus rotundus (nutgrass), widely used in Ayurvedic, Chinese, and traditional medicines, possesses antioxidant, anti-inflammatory, vasodilator, and cardioprotective activities linked to its rich phytochemical profile.