A Plasmonic “Lid‐Off” Nanoplatform for Spatiotemporally Controlled PA/NIR‐II Dual‐Modal Imaging and Cuproptosis‐Based Synergistic Photothermal and Chemodynamic Therapy

shell tightly encapsulates the NIR-II dye CH1055, ensuring its dormant state during systemic circulation. Upon the 1064 nm laser irradiation, localized surface plasmon resonance (LSPR) induces rapid photothermal disruption of the lid, thereby achieving a light-gated "lid-off" effect. This effect synchronously enables high-contrast NIR-II fluorescence/photoacoustic dual-modal imaging and initiates on-demand trimodal therapy integrating photothermal ablation, chemodynamic therapy, and cuproptosis. The single near infrared wavelength-triggered design achieves remarkable suppression of Mouse prostate carcinoma (RM-1) prostate tumor progression with no detectable systemic toxicity. Thereby, our work establishes the "lid-off" nanoarchitecture as a robust platform for spatiotemporally precise, imaging-guided multimodal cancer theranostics.