Association Between Venlafaxine Exposure And Treatment Outcomes In Older Adults With Depression: Association entre l’exposition à la venlafaxine et les résultats du traitement chez les personnes âgées atteintes de dépression
= 0.02).ConclusionOur findings suggest a potential threshold effect, where venlafaxine-related exposure past a certain level did not enhance antidepressant response but increased adverse-effect burden. These results support incorporating exposure measures from therapeutic drug monitoring in antidepressant studies to address the heterogeneity of safety and tolerability outcomes.
Authors
- Laura B. Ramsey (ORCID: https://orcid.org/0000-0001-6417-3961)
- Eric J. Lenze (ORCID: https://orcid.org/0000-0002-0471-9368)
- Victoria Marshe (ORCID: https://orcid.org/0000-0002-1762-4819)
- Zachary L. Taylor (ORCID: https://orcid.org/0000-0001-5178-2397)
- Xiaoyu Men (ORCID: https://orcid.org/0000-0003-1594-666X)
- Cristiana Stefan
- Daniel J. Müller
- Benoit H. Mulsant (ORCID: https://orcid.org/0000-0002-0303-6450)
- James L. Kennedy (ORCID: https://orcid.org/0000-0002-8733-3806)
- Daniel M. Blumberger (ORCID: https://orcid.org/0000-0002-8422-5818)
- Charles F. Reynolds
- Jordan F. Karp (ORCID: https://orcid.org/0000-0002-5171-5028)
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Children's Mercy Hospital (US)
- Centre for Addiction and Mental Health (CA)
- University of Arizona (US)
- University of Pittsburgh (US)
- University of Toronto (CA)
- Columbia University Irving Medical Center (US)
- Ontario Shores Centre for Mental Health Sciences (CA)
- University of Missouri–Kansas City (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- The Canadian Journal of Psychiatry
- Published
- 2026-05-14
- DOI
- https://doi.org/10.1177/07067437261451057
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 0.00