Prelamin A in an <i>Lmna</i> <sup>L648R/L648R</sup> Mouse Model Does Not Promote Atherosclerosis or Vascular Smooth Muscle Loss
BACKGROUND: that lead to expression of an internally truncated, farnesylated prelamin A variant called progerin, which induces loss of vascular smooth muscle cells. Some studies have also reported that accumulation of full-length farnesylated prelamin A, which is normally completely processed to mature nonfarnesylated lamin A, can also drive vascular pathology during physiological aging. METHODS: mice that develop hyperlipidemia on a high-fat diet. RESULTS: mice at 52 weeks of age. There were no differences in proliferation or apoptosis of aortic media cells. CONCLUSIONS: mice.
Authors
- Leroy C. Joseph (ORCID: https://orcid.org/0000-0003-4199-3689)
- George Kuriakose
- Cecilia Östlund (ORCID: https://orcid.org/0000-0001-7810-9688)
- Howard J. Worman (ORCID: https://orcid.org/0000-0002-7063-7889)
- Yuexia Wang (ORCID: https://orcid.org/0000-0001-5461-7469)
- Susan Michaelis (ORCID: https://orcid.org/0000-0001-5851-5021)
- Wei Hsu (ORCID: https://orcid.org/0000-0001-6738-6030)
Institutions
- Harvard University (US)
- Johns Hopkins University (US)
- Agricultural Development Advisory Service (United Kingdom) (GB)
- Johns Hopkins Medicine (US)
- Harvard University Press (US)
- Dana-Farber/Harvard Cancer Center (US)
- Harvard Stem Cell Institute (US)
- Columbia College (CA)
- Columbia University (US)
Publication Details
- Journal
- Arteriosclerosis Thrombosis and Vascular Biology
- Published
- 2026-05-14
- DOI
- https://doi.org/10.1161/atvbaha.126.324400
- Primary Topic
- Nuclear Structure and Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00